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Superoxide is then converted to hydrogen peroxide by the antioxidant enzymes superoxide dismutases (SOD1 and SOD2)

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After 2448 h, the cells were incubated with 100 nM TRaQ-G ligand for 1 h

Ethics declarations Ethics approval and consent to participate The study was approved by the Ethics Committee of Daping Hospital, Army Medical University (NO.2023-137-01)

For example, melatonin can not only directly clean ROS but also promote antioxidant enzymes such as GPx and glutathione reductase, thereby indirectly scavenging ROS