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If post-discontinuation weight measurements were excluded from a particular analysis and replaced by model predictions, the treatment effect would represent a hypothetical situation in which all participants tolerated and adhered to the treatment

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Functional impairment documentation Clinical rationale for surgical intervention Documented failed conservative treatment Radiographic evidence of joint degeneration Without authorization, the claim is denied regardless of clinical appropriateness and many payers do not allow retroactive authorization for elective joint replacement

This side effect can be uncomfortable but is generally not serious if treated promptly