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doi:10.3389/fmicb.2017.01884 47

Barbeau-Grgoire M, Otis C, Cournoyer A, Moreau M, Lussier B, Troncy E

In cells with mutated IDH, this enzyme instead produces 2-hydroxyglutarate (2-HG), a metabolite that inhibits -KG-dependent epigenetic enzymes and contributes to the aberrant epigenetic landscape seen in various diseases, particularly tumors