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Promelanogenic effects by an Annurca apple-based natural formulation in human primary melanocytes

Importantly, converging clinical and preclinical data support a bidirectional interplay whereby circadian disruption and sleep disorders not only emerge early in the disease course, but also aggravate neurodegenerative processes and deeply affect the quality of life of patients and caregivers, underscoring the potential of circadian-based interventions as disease-modifying strategies [13]