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[1] Smoking increases the risk of disease and may worsen eye problems

3.3 A possible thyroid-gut-microbiome-brain axis increases the risk of depression The human microbiota has been found to be a key regulator of health and diseases, and more and more evidence has pointed out their relevance to many human diseases (139)

doi: 10.1038/s41598-022-24694-5 Shi, Naiqi, Szanto, Tibor G., He, Jia, Schroeder, Christina I., Walker, Andrew A., Deuis, Jennifer R., Vetter, Irina, Panyi, Gyrgy, King, Glenn F

For example, no rodent models that can replicate all the common behavioral symptoms of PD, which limits the choice of animal models depending on the specific behavioral trait being studied (Wilson et al., 2008)