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These key mediators can activate signal transduction cascades as well as induce changes in transcription factors, such as nuclear factor kappa B (NF-B), signal transducer and activator of transcription 3 (STAT3), hypoxia-inducible factor-1 (HIF1-), activator protein-1 (AP-1), nuclear factor of activated T cells (NFAT) and NF-E2 related factor-2 (Nrf2), which mediate immediate cellular stress responses (Figure 2)

doi: 10.3390/microorganisms11081896 234 ThomasA.ThomasA.Butler-SanchezM

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Their popularity is also driven by the pursuit of anti-aging solutions

Most antioxidants have a short lifespan, sacrificing themselves whenever they wipe out a free radical