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A more recent advance is mtDNA base editing, which utilizes engineered deaminase enzymes (e.g., DddA-derived cytosine base editors) to catalyze CG to TA base conversions in double-stranded mtDNA without creating double-strand breaks

doi:10.1093/tropej/fmi074

It is when your body recalibrates

Shiu SY, et al

Unfortunately, that can make it harder for people with gastrointestinal disorders to absorb a sufficient amount of the nutrient from the foods they consume