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This result is consistent with previously published reports, which revealed that the lower value of HLB means reduced hydrophilicity and increased the amount of drug that encapsulated into the vesicles, resulting in the higher the encapsulation resulted EE% 35

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Colchicine was also found to bring about the inhibition of the assembly of the NLRP3 inflammasome thus resulting in the inhibition of the expression of pro-inflammatory cytokines including IL-1

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