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A meta-analysis which was performed on 13 studies up until 2016 had shown that there were significant differences in expression in IBS patients compared to healthy controls for Lactobacillus , Bifidobacterium , and Faecalibacterium prausnitzii

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Yang F, Haile DJ, Wang X, Dailey LA, Stonehuerner JG, Ghio AJ

Zhang Y, Hu T, Hua C, Gu J, Zhang L, Hao S, et al

Moreover, neither serological testing nor polymerase chain reaction (PCR) can reliably distinguish active infection from asymptomatic carriage, creating significant challenges for clinicians in determining whether and when to initiate antimicrobial therapy (Spuesens et al., 2014