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Eighteen rabbits were categorized into three distinct groups: normal control (N), high-cholesterol diet (HCD), and HCD + ALA groups (4.2 mg/kg body weight) over a period of 10 weeks

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As lipHA-hEVs can reduce P-gp expression in resistant MCF7/ADR cells, loading doxorubicin onto lipHA-hEVs effectively inhibited its efflux, thus overcoming doxorubicin resistance [210]