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In this light, neutrophils and NETosis are not merely participants but drivers of PCOS pathophysiology, offering a unifying conceptual framework and a roadmap for next-generation translational research

Reduced inorganic sulfate or cysteine (secondary to GSH depletion) can cause cosubstratedependent decrease in sulfation rates

Importantly, NNMT is a dominant component of the gene expression signature for sarcopenia, overexpression of which could lead to significantly reduced levels of NAD+ and associated declines in muscle mass, strength, and function that accompany aging

19, 73 It is not known whether those muscular abnormalities are usually primary pain generators (giving rise to associated secondary bladder pain) or are themselves secondary phenomena elicited by the primary bladder pain of IC/BPS

This approach may offer rapid relief and promote healing at the site of the lesion