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"Hypervitaminemia B12 in the Elderly: A Forgotten Marker of Serious Underlying Diseases"

Cell Metabolism, 27 (3), 513-528

Pieper emphasized that currently available over-the-counter NAD+ precursors have been shown in animal models to raise cellular NAD+ to dangerously high levels that promote cancer. This conclusion extrapolates beyond the published findings and lacks support from human clinical evidence