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NAT10 drives cisplatin chemoresistance by enhancing ac4C-associated DNA repair in bladder cancer

These findings indicated that iron deficiency treatment could decrease iron abundance and impair tumor growth in the two in vivo models

Wang H, An P, Xie E, Wu Q, Fang X, Gao H

Out of 12 studies, ONLY 3 involved dietitians, and systematic assessment of protein or micronutrient intake was almost entirely absent

GSH depletion causes ferroptosis in RPE cells To evaluate the mechanism of cell death in GSH-depleted cells, we treated RPE cells with various cell death pathway inhibitors including ferroptosis inhibitors ferrostatin-1 (Fer-1, 8 M), liproxstatin-1 (Lip-1, 600 nM), iron chelator deferoxamine (DFO, 80 M), pan-caspase inhibitor z-VAD-fmk (30 M) to inhibit apoptosis, autophagy inhibitor 3-methyladenine (3-MA, 10 mM), and lysosomal inhibitor bafilomycin A1 (Baf-A1, 75 nM)