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As a water-soluble vitamin, excess amounts are excreted through urine

Kobets T, Smith BPC, Williams GM

Fas is a member of the death receptor family that induces apoptosis through binding to the Fas ligand

These effects may be magnified in individuals with chronic diseases that have an inflammatory component (e.g., obesity, diabetes, heart disease), as well as in those with age-related, low-grade inflammation, also known as inflammaging