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Aging A 2014 report by the Aging Research team led by Professor Sinclair of Harvard Medical School showed that NMN can extend the lifespan of mice by targeting the SIRT2 pathway through NAD + and enhancing the expression of the checkpoint kinase BubR1, which declines with age [27]

Metformin therapy and cognitive dysfunction in patients with type 2 diabetes: a meta-analysis and systematic review

Additionally, inhibition of CD38 in the AD mouse model restored NAD + levels, decreased mitochondrial ROS production and plaque depositions in the hippocampus and cortex, and improved cognitive abilities 158