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doi:10.1016/j.maturitas.2022.07.014

U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia

S mainly impairs mitochondria by reducing MMP and ATP production, increasing fragmentation and oxidative stress

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Also, evidence from a population-based study indicates that obstructive sleep apnea is consistently associated with accelerated epigenetic ageing, while the impact of insomnia and sleep deprivation appears to be modulated by the duration of NSW schedule, highlighting a complex interplay between sleep disturbances, NSW, and biological aging 240