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MYCN abundance modestly influenced sensitivity: MYCN downregulation in IMR-5/75 cells slightly reduced toxicity, while MYCN induction in SH-SY5Y/MYCN slightly increased it, though neither change reached significance

Response to neoadjuvant therapy Restaging imaging exams after completion of neoadjuvant therapy are primarily performed to rule out the presence of local progression or metastatic disease before proceeding to definitive local therapy

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced (see DOSAGE AND ADMINISTRATION)

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