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Regarding oxidative stress associated with mitochondrial complex I dysfunction and its role in BD, the importance of glutathione, an endogenous antioxidant, in preventing oxidative damage has been highlighted

The modeling of TM16-TM17 allows the identification of putative residues for the stimulated transport of GSH The above results led us to conclude that among the expressed chimeras, M8 is the most significantly affected both for inducing CS and for its GSH-dependent transport activity

83,84,85,86,87 NF-B is a transcription factor responsible for improving the transcription of various inflammation-associated proteins, including pro-interleukin-1 (pro-IL-1), when secreted in the extracellular space

Small molecules targeting HDAC6 for cancer treatment: current progress and novel strategies

Sakamoto I, Kishida S, Fukui A, Kishida M, Yamamoto H, Hino S, et al