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Each cohort consisted of 10 patient cases, and the ALS cases were classified as sporadic cases with no known genetic mutations

While our in vitro results show a putative role for senescence in immune cell functional changes during killifish aging, whether the molecular and cellular changes occurring in the killifish kidney marrow during aging lead to systemic functional consequences remains to be assessed in more detail

BoidoMPirasAValsecchiVSpigolonGMareschiKFerreroIet al

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These pharmacological effects demonstrate how external factors, such as medication, can alter the regulation of melanin and contribute to hair depigmentation