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Although xCT-GPX4-GSH is considered to be the primary mechanism that prevents ferroptosis, inhibition of GPX4 or GPX4 knockout fails to trigger ferroptosis in certain cancer cell lines, suggesting alternative resistance mechanisms[79, 91-93]

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BMC Med 21(1):3 Zhang Y, Xu W, Wu M, Li Y, Chen G, Cheng Y et al (2024) Survival risk stratification based on prognosis nomogram to identify patients with esophageal squamous cell carcinoma who may benefit from postoperative adjuvant therapy

10.1159/000495382 149 RobertsL