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Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems

Dickinson, L.A., Dickinson, C.D

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impairment of COX can lead to mitochondrial dysfunction, alterations in mitochondrial membrane permeability, and subsequent mitochondrial dysregulation

Furthermore, the study NCT01303796, a Phase III clinical trial involving 482 AML patients, evaluated the efficacy of DAC (20 mg/m 2 once daily for 5 consecutive days every 8 weeks) + sapacitabine (300 mg twice daily on 3 consecutive days per week for 2 weeks every 8 weeks), an oral nucleoside analog