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This work was supported by Guangxi Science and Technology Project (Guangxi Science and Technology Base and Talent Special Project: Guike AD24010014), Guangxi Key Laboratory of reproductive health and birth defect prevention (21-220-22), Guangxi Clinical Research Center for Pediatric Diseases (Guike AD22035121), Self-Funded Program of Guangxi Health Commission (Z-A20240319), Guangxi Key Laboratory of Birth Defects and Stem Cell Biobank (ZTJ2020002)