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Our molecular docking results revealed that the free binding energies of the five core genes with puerarin were as follows: HIF1A-PUE ( 3.45 kcal/mol), mTOR-PUE ( 3.78 kcal/mol), PTGS2-PUE ( 4.44 kcal/mol), RELA-PUE ( 3.42 kcal/mol), and GSK3-PUE ( 3.03 kcal/mol)