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One pivotal trial followed patients taking 600mg of racemic ALA daily for four years and found no significant safety concerns.7 We explore the differences between racemic ALA and R-ALA later in the guide, but its worth noting here: racemic ALA has the strongest long-term safety data in humans

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first discovered plasma intestinal flora-dependent small molecule metabolic spectrum by metabonomics and found that the plasma levels of TMAO and its precursors, choline and betaine, can predict the risk of human cardiovascular disease, thus identifying a novel relationship between intestinal flora and metabolic health (7)

Basal expression levels were used for the analyses of correlations