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The results of almost 20 years of study by the Columbia group confirmed what they described as the pharmacologic dissection of depressive subtypes: that is, that while patients with typical melancholic depression respond to a range of antidepressant agents, those with atypical depression respond preferentially to MAOIs and fail to respond to TCAs.20,40,41 Since then, other studies have shown that patients with atypical depression appear to be more likely to respond to MAOIs.40,4244 Liebowitz et al40 conducted the largest of these trials in 119 patients with depression, mood reactivity, and at least 2 other symptoms suggestive of atypical depression (eg, overeating, oversleeping, extreme fatigue while depressed, oversensitivity to rejection)

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Both are powerful IV therapies but serve different purposes