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Aging (Albany NY) 14(8):34643483 Shigenaga MK, Hagen TM, Ames BN (1994) Oxidative damage and mitochondrial decay in aging

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For instance, systemic administration of iron chelators such as deferoxamine or deferasirox effectively reduces Fe + levels and lipid peroxidation but carries the risk of disrupting systemic iron metabolism, potentially causing anemia, immune dysfunction, and impaired wound healing (53, 196, 197)

Overexpression of redox-regulating enzymes such as thioredoxin and glutamatecysteine ligase in patients with DLBCL has been reported to lead to poor prognosis owing to the ability of tumor cells to cope with oxidative stress from ROS-generating anticancer drugs such as doxorubicin, vincristine, and cyclophosphamide [35]

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