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Kojic acid and arbutin remain the classic compounds that can be topically used as skin-lightening agents in a clinical setting due to proven efficacy

Lavy M, Estelle M

4 However, if patient exhibited more than mild hepatic dysfunction, reduced cyclophosphamide dosing should be considered

The tumor microenvironment is known for its pivotal role in immune evasion, with tumor-associated macrophages, myeloid-derived suppressor cells, and regulatory T cells creating an immunosuppressive niche that sustains GBM growth

The ability of cells to increase L-2-HG in hypoxic conditions to regulate histone methylation levels, including H3K9me3 and to reduce cellular reductive stress by inhibiting key metabolic pathways indicates an important physiological role of L-2-HG 48, 50