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Increased concentrations of SCFAs in systemic circulation play an anti-inflammatory role far beyond the gut by immune modulation (Yao et al., 2022)

Furthermore, certain drugs, for example salicylates and phenytoin, displace thyroid hormones from their binding proteins, thus reducing total, but not free, hormone concentrations once a new steady state is attained

Congruently, the loss of KAT6A results in a shift in the expression of HOX genes (body segment identity), and the reduction in the expression of DLX genes (jaw and palate development) and TBX genes (heart development), among other affected genes (Voss et al, 2009, 2012