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184 In addition, depleting Cu in HER2/neu transgenic mice causes tumor shrinkage, suppresses angiogenesis, and inhibits the progression from microscopic to macroscopic tumors

Besides, Bow and coworkers demonstrated that local delivery of angiogenesis-inhibitor minocycline could potentiate the anti-tumor efficacy of radiotherapy (RT) and oral temozolomide, as evidenced by enhanced OS in a rodent glioma model [153]

Xu X, Huang E, Tai Y, Zhao X, Chen X, Chen C, et al

Morgillo F, Della Corte CM, Fasano M, Ciardiello F