l-lysine and l-carnitine together benefits dietary supplementation for childhood adolescent growth: Promises and precautions Biosynthesis of L-Carnitine from lysine

After entering the cochlea, cisplatin is taken up into cells by diffusive and passive transport, copper transporter protein 1 (Ctr1) and organic cation transporter protein 2 (OCT2), endocytosis, and toxicity through DNA adduct formation, oxidative stress, mitochondrial dysfunction, inflammatory response, and ferroptosis ( 2.1 Cisplatin-induced DNA damage and apoptosis Once cisplatin enters the cell it can be hydrolyzed to form toxic aqua-cisplatin complexes and form intra-and interstrand crosslinks with DNA (Figure 1) FIGURE 1 2.2 Cisplatin induces oxidative stress The cochleas high metabolic rate results in its production of abundant reactive oxygen species (ROS), so it requires an active antioxidant defense system [glutathione (GSH), oxidized glutathione (GSSG), and antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR)] to achieve a dynamic oxidant-antioxidant balance to maintain healthy hearing

Nevertheless, circadian disruption is detrimental to bone metabolism and bone mass and may lead to osteoporosis

Vitamin-Rich Botanical Butters: Shea, mango, and kokum butters are naturally rich in skin-loving vitamins and fatty acids, helping maintain moisture, comfort, and a supple skin feel without clogging pores

Improves skin, hair, and nails

Zhao L, Wang M, Sun Y, Xu J, Fu Q, Xiao W