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Apart from multifactorial interventions, alternatives to caloric restriction can include environmental conditioning and caloric restriction mimetics, including rapamycin, metformin, or a blend of micronutrients and bioactives, including quercetin, rutin, curcumin, genistein, resveratrol, epigallocatechin gallate, gallic acid, betaine, theanine, -aminobutyric acid, diallyl sulforated compounds, NAD + precursors, coenzyme Q10, vitamins, plant polysaccharide, plant-derived peptides, and others

Ferroptosis, a nonapoptotic form of cell death, is featured by the excessive iron-dependent accumulation of lipid reactive oxygen species (ROS) [11,12,13]

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