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CD8 + Tcell response displayed markedly increased levels of interferon (IFN), cytolytic proteins perforin 1 (PRF1) and granzyme B (GZMB), cytotoxic T lymphocyteassociated antigen 4 (CTLA4), and tumor necrosis factor alpha (TNF

For patients who had been randomized to HTD1801, the baseline biochemical characteristics of MRI responders were indicative of more severe disease compared to MRI non-responders (Table 1)

Early-phase trials of liposomal (Lipocurc) and polymeric (NanoCurc) curcumin demonstrate target engagement and biological activity but underscore persistent bioavailability challenges and dose-limiting toxicities (e.g., hemolysis at 300 mg/m)

Youngblood et al., 2020

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