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These tumors exhibit dependencies on serine hydroxymethyltransferase (SHMT)-mediated pathways that represent novel therapeutic vulnerabilities [64, 65]

Since a divalent ion of [M + 2 H] 2+ of GSSG ( m/z 307) was also abundant as well as an ion of [M + H] + GSSG ( m/z 613) at full ion scan mode, the divalent ion was also chosen as precursor ion to obtain target product ion of m/z 84.10 (CE 26 V)

Nat Commun 10 , 4511 (2019)

Additionally, EGCG regulates the UPR, helping cells manage protein folding stress without triggering apoptotic pathways, which is particularly relevant in HD [90]

Deletion of S100a8 and S100a9 enhances skin hyperplasia and promotes the Th17 response in imiquimod-induced psoriasis