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Factorial experimental designs with single-compound and combined-compound treatment arms, alongside vehicle controls, allow researchers to statistically distinguish independent compound effects from any combination-specific outcomes on NAD+ pathway and mitochondrial redox endpoints, a standard approach in multi-compound cellular metabolism research.

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Rawlings TM, Makwana K, Taylor DM, Mole MA, Fishwick KJ, Tryfonos M, Odendaal J, Hawkes A, Zernicka-Goetz M, Hartshorne GM, Brosens JJ, Lucas ES (2021) Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids