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Historically, there was significant concern for notoriety bias (i.e., increased likelihood of case reporting when patients are exposed to a drug with a negative reputation), which was mitigated by studying disproportionality signals

To overcome lower bioavailability as well as immune response issues, various delivery systems (encapsulation of ACPs in liposomes, polymer nanoparticles, or quantum dots) were used (186)

GLP-1 is a hormone produced naturally in your gut, brain, and pancreas

Consequently, achieving effective drug concentrations in the tumor becomes difficult and ultimately leads to drug resistance in breast cancer