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Furthermore, treatment with amphotericin B, fluconazole, or 5-fluorocytosine improved MASLD phenotypes, including hepatic steatosis, insulin resistance, and obesity, in HFD-fed mice 166

Studies have also shown that enhancing HIF-1 expression in adipose-derived stem cells (ADSCs) improves both osteogenic and angiogenic capacities, highlighting HIF-1 as a key transcriptional regulator of cellular function via the HIF-1/VEGF/AKT/mTOR pathway (Song S

However, the efficacy of MitoQ in human studies is limited (Snow et al., 2010), and more clinical trials are required to evaluate its therapeutic effects on hearing loss patients

Age of onset of clinical manifestations ranged from birth to early infancy with one prenatal onset of oligohydramnios, severe intrauterine growth retardation, and periventricular cysts [60]