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Upregulation of brain cholesterol levels inhibits mitophagy in Alzheimer disease

and 5^* and 2^* is the multiplicity of the dilution of the serum and the protein removing reagents after mixing

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Vitamin C functions optimally in an acidic environment (pH 3.5 or lower), while retinol prefers a neutral to slightly alkaline environment (pH 6-7)

The orientation of NADPH within the crystal structure of the SmTGR (U597C)NADPH complex (Figure 2), along with a previously performed kinetic isotope effect with Pro-S NADPD (Smith et al., 2023), establishes that the hydride transferred to the FAD of SmTGR from NADPH is from the Pro-S position and permits assignment of the observed NMR signals