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Hospira is owned by Pfizer and follows strict standards for its bacteriostatic water

Each freeze-thaw cycle stresses the peptide in solution and can cause aggregation, the process by which peptide molecules clump together and lose biological activity

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This means semaglutide users often add more water (2-3mL) to keep lower doses measurable, while retatrutide users at higher doses may prefer less water (1mL) to keep injection volumes manageable