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Allosteric regulation of ARs transcriptional activity The mechanistic insights reported above are consistent with allosteric regulation of transcription factor action, in which the type of DNA motif to which the factor binds and its protein and ligand interactions influence its conformational plasticity and the availability of tunable multimerization and protein interaction surfaces that control context-dependent and gene-specific transcriptional activity [78, 80]

Reversal of stable behavioural modifications through NMDA receptor inhibition in rats

Based on these findings, L-carnitine may modulate pro-inflammatory cytokine production in the testicular microenvironment by preserving Leydig cell function, which in turn could support testosterone synthesis and release

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Pasiakos, Stefan M et al