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upregulation of antioxidant enzymes like catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR) glutathione peroxidase (GPx), heme oxygenase, endothelial nitric oxide synthase, and other protective proteins ( In addition to the above biological functions, carnitine also plays an important role in anti-apoptosis and protection of mitochondrial biogenesis and integrity, which are beyond the scope of this study ( Application in Diseases Carnitine, a natural compound closely related to the above-mentioned functions, has recently been found to alter the underlying disease pathology with fewer side effects ( Role of Carnitine in the Pathogenesis of NAFLD and Associated Diseases Carnitine and Multiple Hit Hypothesis in the Pathogenesis of NAFLD The prevalence of NAFLD is increasing at a tremendous rate, currently affecting about 24% of the world's population

Am J Clin Nutr 2009 , 89 , 7176 [8] Manta-Vogli, P.D

Chen C, Krausz KW, Shah YM, Idle JR, Gonzalez FJ

NCHS Data Brief 18

doi:10.1016/j.cnp.2019.01.005 Venhovens J, Meulstee J, Verhagen WIM