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Simm, Redox Biology Role of advanced glycation end products in cellular signaling, Redox Biol

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Effect of MTX on serum total and free carnitine levels in carnitine-depleted and supplemented rats The impacts of MTX on serum total and free carnitine concentrations in carnitine-depleted and supplemented rats are presented in Fig

What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide