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Preclinical studies have demonstrated that transplanting fecal microbiota from patients with MDD to rodents induced depression-like behaviors, including anhedonia and anxiety-like behaviors, and altered tryptophan metabolism, while microbiota transfer from healthy donors reversed these behavioral phenotypes (Kelly et al., 2016

It has been reported that oral administration of glutathione did not change the levels of glutathione and glutathione disulfide in the deproteinized fraction of blood, and it has been suggested that orally administered glutathione is degraded into constituting amino acids and does not exert specific activity beyond the amino acid source. Yasushi Honda et al

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In addition to producing the main methyl donor, methionine is also indirectly involved in the synthesis of polyamines, which are crucial for cell growth