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Avoid mixing copper peptides with strong, lowpH actives like highstrength vitamin C (ascorbic acid), aggressive AHAs/BHAs (glycolic, lactic, salicylic acid), and potent retinoids in the same step, as they can destabilize peptides or increase irritation

clarified this dilemma by using CRISPR-Cas9 to introduce the risk variant, a non-risk control, and a PTPN22 knockout into human cord blood-derived nave T cells from the same donor

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Our screening method can be employed in future searches for novel pharmacologic inhibitors, thus providing an approach for accelerating drug deployment, concludes the team