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Patients should be reviewed 812 weeks after commencing treatment to assess: Symptomatic improvement, particularly resolution of fatigue and neurological symptoms Haematological response (normalisation of haemoglobin and mean cell volume) Reticulocyte count typically rises within one week, indicating bone marrow response Repeat serum B12 testing is generally not useful after starting parenteral therapy, as levels remain elevated for months

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No one has tested whether the effects are additive, synergistic, or negligible when combined

Many of these commenters stated that maintaining voluntary reporting appropriately acknowledges the ongoing concerns around provider burden while still allowing hospitals to report data as they are able and avoiding punitive consequences for non-compliance