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Organ weights were recorded for liver, kidney, heart, epididymal adipose tissue, interscapular brown adipose tissue, and spleen (Data Source File 1)

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The media are classified into anion exchangers and cation exchangers

Exclusion criteria were as follows: no defined geographical region, less than 1 year of data, study population limited to paediatric cases only, self-reported cases identified by survey, reviews and clinical trials

Gentamicin and streptomycin are relatively more vestibulotoxic, while tobramycin affects both cochlear and vestibular structures ( Otoprotective agents Several compounds have demonstrated otoprotective potential in preclinical models, though clinical translation remains limited, and none are currently recommended as standard of care outside clinical trials