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Cardiac-specific overexpression of acyl-CoA synthetase-1 (ACSL1) in mice has been shown to mitigate pressure overload-induced cardiac dysfunction by reducing toxic lipid accumulation, restoring long-chain acyl-CoA levels, and enhancing mitochondrial bioenergetics

hence it is recommended only as a short-term therapy

Patients treated with a DTG-based regimen had a two-fold higher risk of developing hyperuricemia, which was in agreement with a study finding from China (59), which showed the number of patients with hyperuricemia increased with DTG-containing ART