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554 Astrocyte pathology is a fundamental, if not leading, factor in neuronal death: astrocytes in ALS lose their capability to sustain neurones, to clear glutamate and they some aberrant astrocytic forms are generated, which may cause direct damage

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Eur Rev Med Pharmacol Sci (2017) 21:89101

Instead, it is biosynthesized from methionine via a multi-step process that probably occurs in every cell of the body (Figure 1)

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