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Disclosure of interest: Xiaoqing Jiang, Zixiao Li, Yongjun Wang:nothing to disclose Poster Session I - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.03 - EPIDEMIOLOGY & RISK FACTORS P413 - ESOC25-196 INVESTIGATING CARDIOVASCULAR RISK AS A MODERATOR OF THE RELATIONSHIP BETWEEN BLOOD-BASED DEMENTIA BIOMARKERS AND COGNITIVE IMPAIRMENT A CROSS-SECTIONAL ANALYSIS OF DATA FROM THE BIO-HERMES STUDY Angelina Kancheva 1 , Donald Lyall 2 , Terence J Quinn 3 1 School of Cardiovascular & Metabolic Health, University of Glasgow, University of Edinburgh, Glasgow, United Kingdom, 2 School of Health & Wellbeing, University of Glasgow, Glasgow, United Kingdom, 3 School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, United Kingdom Background and Aims: Blood-based biomarkers may enhance diagnosis and prognosis of Alzheimers disease (AD) and other dementias