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doi: 10.3389/fgene.2022.1079455 Received 05 November 2022 Accepted 28 December 2022 Published 09 January 2023 Volume 13 - 2022 Edited by Qinghai Huang, Changhai Hospital, China Reviewed by Alexey V

Neurologic symptoms The neurologic symptoms of vitamin B 12 deficiency are myriad and include numbness and tingling of the hands and, more commonly, the feet (peripheral neuropathy)

a concentration which is just below their perception threshold (2.5 10 9 g/ml) 20 and to MP 10 6 g/ml as a control after washing

Due to their excellent biocompatibility, targeting ability, and high stability, they can serve as a potentially effective drug delivery system

However, there are still a lot of questions that remain to be answered about the relationship between folate levels in the colonic mucosa and the systemic circulation and the colorectal cancer risk, and about the role of folate derived from the diet and that from local microbial production 287,288,289,290