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In the body, the placental barrier, blood-testis barrier (BTB), and bloodbrain barrier (BBB) are permeable to F [7,8,9,10,11]

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Because of its metabolic role, NNMT is expressed in liver, adipose tissue, kidney, and other tissues

Furthermore, PA successfully reversed hepatotoxicity in CCl4-induced hepatic fibrosis rats via the underlying mechanisms of regulating serum enzymes and attenuating TNF-/NF-B pathway for anti-inflammation response, as well as improving metabolic function in liver tissue, which might be one of the regulator mechanisms of antifibrosis (Li et al., 2013)